If you follow skincare closely, you've probably started seeing PDRN appear in your feeds. Korean dermatology clinics have been using it for years. Global beauty editors named it one of the defining treatments of 2026. And Irish clients are beginning to ask about it.
At Haku, we are one of the first clinics in Ireland to offer PDRN as a clinical facial treatment — using the Genosys Bio-Meso system, the same professional-grade protocol used in South Korean aesthetic clinics. This is what PDRN is, how it works, and whether it might be right for your skin.
What is PDRN?
PDRN stands for polydeoxyribonucleotide — a naturally derived molecule extracted from salmon DNA. Despite the name, there is nothing unusual about this. Salmon DNA shares a high degree of compatibility with human DNA, which is precisely what makes PDRN so effective as a skin ingredient. It is biocompatible, meaning the body accepts it readily rather than treating it as a foreign substance.
PDRN has been used in wound healing and tissue regeneration in medical settings for decades. Its application in aesthetic skincare is newer — but the science behind it is well established. PDRN works by stimulating the A2A adenosine receptor in the skin, triggering a cascade of cellular repair and regeneration. In plain terms: it tells your skin cells to repair themselves.
The result is skin that rebuilds from within — more collagen, better hydration, improved elasticity, and a reduction in scarring and hyperpigmentation over time.
How is PDRN different from other treatments?
Most clinical facials work by either resurfacing the skin from the outside (peels, lasers, microneedling) or delivering active ingredients into the skin. PDRN does something more fundamental — it activates the skin's own repair mechanism at a cellular level.
This is why PDRN is often described as regenerative rather than corrective. Other treatments remove or resurface. PDRN rebuilds. The two approaches work well together, which is why PDRN is often used as a standalone treatment or combined with microneedling for deeper results.
Compared to hyaluronic acid skin boosters, which primarily hydrate, PDRN goes further — it stimulates actual tissue regeneration rather than just temporarily plumping the skin.
What is the Genosys Bio-Meso PDRN treatment at Haku?
Genosys is a professional Korean aesthetic brand whose products are used in clinical settings across South Korea, Japan, and Europe. Their Bio-Meso PDRN system is a clinical-grade protocol that delivers PDRN into the skin using micro-spicules — tiny natural structures that create microscopic channels in the skin without needles.
This needle-free delivery method makes the Genosys Bio-Meso PDRN treatment comfortable, accessible for most skin types, and requires minimal downtime compared to injectable PDRN treatments.
At Haku, we use Genosys products across our clinical treatments — the same brand that supplies our microneedling serums and post-treatment aftercare. We chose Genosys because the clinical standard is consistent with what we want to deliver: professional-grade results in a calm, considered environment.
The Bio-Meso PDRN facial is available at both our Ranelagh and Blackrock locations.
What does the treatment involve?
A Genosys Bio-Meso PDRN facial at Haku takes approximately 60 minutes. Here is what to expect:
- Consultation and skin assessment: Your therapist will assess your skin and discuss your primary concerns — scarring, hyperpigmentation, dehydration, loss of elasticity, or general skin quality.
- Cleansing and preparation: The skin is thoroughly cleansed and prepared for treatment.
- Bio-Meso application: The Genosys Bio-Meso PDRN serum is applied to the skin. Micro-spicules within the formula create microscopic channels that allow the PDRN to penetrate into the dermis — the deeper layer of skin where regeneration occurs.
- Absorption and recovery: A soothing mask or recovery serum is applied. The skin will appear slightly flushed immediately after — this settles within a few hours.
- Results timeline: Most clients notice improved hydration and a luminous quality within 48–72 hours of their first treatment. Deeper improvements to scarring, pigmentation, and skin texture develop over several weeks as the regenerative process unfolds.
Who is PDRN suitable for?
The Genosys Bio-Meso PDRN treatment is suitable for a wide range of skin concerns and types:
- Acne scarring — PDRN accelerates the natural remodelling of scar tissue, improving texture and reducing the appearance of post-acne marks over a course of treatments.
- Hyperpigmentation — PDRN supports more even cell turnover, gradually brightening uneven skin tone.
- Dehydrated or dull skin — PDRN restores the skin's capacity to retain moisture at a cellular level, producing a lasting improvement rather than temporary plumping.
- Ageing skin and loss of elasticity — collagen stimulation from PDRN gradually improves skin firmness and reduces fine lines.
- Sensitive or compromised skin — unlike more aggressive treatments such as peels or laser, PDRN is gentle and well tolerated by sensitive skin types, including rosacea-prone skin.
- Post-treatment recovery — PDRN is an excellent follow-up treatment after microneedling, laser, or chemical peels, accelerating healing and amplifying results.
PDRN is not recommended during pregnancy or breastfeeding, or if you have an allergy to fish or fish products.
How many sessions are needed?
A single Bio-Meso PDRN session produces noticeable results — particularly in terms of hydration and skin quality. For more significant changes to scarring, pigmentation, or skin texture, a course of three to six sessions spaced two to four weeks apart is recommended.
Many clients incorporate PDRN as a monthly maintenance treatment alongside their regular facial routine, or use it as a recovery treatment following more intensive clinical work such as microneedling or Fraxel laser.
PDRN at Haku Dublin — pricing and booking
Genosys Bio-Meso PDRN Facial: from €200 per session
Available at:
- Haku Ranelagh — 1st Floor, 13 Ranelagh, Dublin 6
- Haku Blackrock — 21 Main Street, Blackrock, Dublin
We recommend a brief consultation before your first PDRN treatment so your therapist can assess your skin and confirm it is the right treatment for your concerns.
Frequently asked questions
What is PDRN?
PDRN (polydeoxyribonucleotide) is a naturally derived molecule from salmon DNA that stimulates cellular repair and regeneration in the skin. It activates the skin's own healing process, producing improvements in hydration, collagen production, scarring, and skin texture over time.
Is PDRN the same as a salmon DNA facial?
Yes — salmon DNA facial is the informal name for PDRN treatments. The active ingredient, polydeoxyribonucleotide, is extracted from salmon DNA because of its high compatibility with human DNA. The Genosys Bio-Meso treatment at Haku uses this ingredient in a professional clinical formulation.
How many PDRN sessions do I need?
A single session improves hydration and skin quality noticeably. For deeper improvements to scarring, pigmentation, or ageing, a course of three to six sessions is recommended, spaced two to four weeks apart.
What is the downtime after a PDRN facial?
Downtime is minimal. Some clients experience slight redness or warmth immediately after treatment, which settles within a few hours. Most clients return to normal activities the same day. This is one of the advantages of the needle-free Bio-Meso delivery method.
Where can I get a PDRN facial in Dublin?
Haku offers the Genosys Bio-Meso PDRN facial at both our Ranelagh and Blackrock Dublin locations. We are one of the first Irish clinics to use the Genosys Bio-Meso clinical protocol. Book a consultation online at haku.ie.
Is PDRN better than microneedling?
They work differently rather than one being better than the other. Microneedling creates controlled micro-injury to stimulate collagen. PDRN activates cellular repair through the skin's own regenerative mechanism. They are highly complementary — PDRN applied during or after microneedling amplifies results and accelerates recovery. At Haku we offer both as standalone treatments or in combination.
Available at Haku Ranelagh and Haku Blackrock. Book a consultation with our clinical team to find out if PDRN is right for your skin.